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PEST sequence
A
PEST
sequence
is a
peptide sequence
that is
rich
in
proline
,
glutamic acid
,
serine
, and
threonine
. This sequence is associated with
proteins
that have a
short
intracellular
half-life
;
therefore
, it is
hypothesized
that the PEST sequence acts as a
signal peptide
for
protein degradation
.
This
protein
degradation
may be
mediated
via
the
proteasome
or
calpain
.
Other
signals
thought to
identify
proteins for degradation include
cyclin
destruction
boxes
, which are
amino acid
sequences
that
mark
cell-cycle
proteins for destruction.