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PEX5
Peroxisomal targeting signal
1
receptor
is a
protein
that in
humans
is
encoded
by the
PEX5
gene.
PTS1R is a
peroxisomal
targeting sequence
involved
in the
specific
transport
of
molecules
for
oxidation
inside
the
peroxisome
.
SKL
binds
to PTS1R in the
cytosol
followed by
binding
to the
Pex14p
receptor allowing
importation
of the peroxisomal protein through the pexsubunit
transporter
.
Diseases
associated with
dysfunctional
PTS1R
receptors
include
X-linked adrenoleukodystrophy
and
Zellweger syndrome
.
Interactions
PEX5 has been
shown
to
interact
with
PEX12
,
PEX13
and
PEX14
.