PPP3CC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform is an enzyme that in humans is encoded by the PPP3CC gene.
Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca-dependent modifier of phosphorylation status.
In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively.
At least 3 genes, calcineurin A-alpha, calcineurin A-beta, and calcineurin A-gamma, have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species.
