PSEN2
Presenilin-2 is a protein that is encoded by the PSEN2 gene.Function
patients with an inherited form of the disease carry mutations in the presenilin proteins or the amyloid precursor protein. These disease-linked mutations result in increased production of the longer form of amyloid-beta. Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.
In melanocytic cells PSEN2 gene expression may be regulated by MITF.Interactions
PSEN2 has been shown to interact with:
