PX domain
The PX domain is a phosphoinositide-binding structural domain involved in targeting of proteins to cell membranes.
This domain was first found in P40phox and p47phox domains of NADPH oxidase. It was also identified in many other proteins involved in membrane trafficking, including nexins, Phospholipase D, and phosphoinositide-3-kinases.
The PX domain is structurally conserved in eukaryotes, although amino acid sequences show little similarity. PX domains interact primarily with PtdInsP lipids. However some of them bind to phosphatidic acid, PtdInsP2, PtdInsP2, PtdInsP2, and PtdInsP3. The PX-domain can also interact with other domains and proteins.Human proteins containing this domain
s contain this domain. Other examples include:
