Salazar was born in Soyaló, Chiapas. He was the son of rural teachers. At age 17 he enrolled in the Autonomous University of Puebla where he obtained the title of Lawyer, Notary and Actuary. He returned to Chiapas in 1978. He is a lay member of the evangelicalChurch of the Nazarene. In 1982, he married Martha López Camacho, with whom he has three children.
He was convicted and imprisoned on charges including embezzlement of 104 million pesos. He was detained on 7June2011. In 2011, Juan Sabines, the governor of Chiapas, repeatedly accused Salazar of corruption and misuse of funds. These accusations came following the 2012 elections. Many suspect that Sabines' attacks were based on speculation that Salazar would again run for public office—which would pose a threat for Sabines' administration. Sabines accused Salazar of stealing 11 billion pesos that had been designated for rebuilding after Hurricane Stan, an accusation that Salazar responded to by publishing a response, "The Truth About Stan." Salazar's office printed 50,000 copies of the document to be distributed throughout the state. At 3AM the morning of June2, Salazar's office in Tuxtla-Gutierrez, Chiapas, Mexico was violently broken into by armed men who restrained the security guards at Salazar's office. All 50,000 copies of the document were stolen. Salazar filed a criminal complaint with the Federal Police to investigate the breakin. On June 7, 2011, Pablo Salazar was arrested at the Cancún airport on charges of embezzlement and criminal association. On June 9, Carlos Loret de Mola, a reporter for the newspaper El Universal, published an article about a “secret” document delivered by an official from the government of Chiapas to the residency of Mexican President Felipe Calderon. The document was entitled “Pablo Salazar Mendiguchia Is a Danger to the Governance of Chiapas.” The document listed various accusations against Salazar, and asked the federal government to either assist in arresting Salazar or have the Secretary of National Defense invite Salazar to exile the country for 18 months. The document was unsigned. On June 14, 2011 Salazar was indicted for alleged acts of corruption. He was not eligible for bail since the charges included abuse of political office.
Release from prison
Salazar was released on November 16, 2012. Salazar was released a few days before his successor, the governor Juan Sabines Guerrero, left office on December 8. Therefore, it was speculated that the arrest may have been simple political rivalry.