Parthenolide

Applications

''In vitro'' biological activities

• Inhibition HDAC1 protein without affecting other class I/II HDACs, which leads to sustained DNA damage response in certain cells.
• Modulation of the NF-κB-mediated inflammatory responses in experimental atherosclerosis.
• Promotion of axon regeneration in the peripheral nervous system with intraneural or systemic application.
• Inducing apoptosis in acute myelogenous leukemia cells, leaving normal bone marrow cells relatively unscathed. Moreover, the compound may get at the root of the disease because it also kills stem cells that give rise to AML.
• Activity against Leishmania amazonensis.
• Microtubule-interfering activity.
• Anti-inflammatory and anti-hyperalgesic effects.
• Blocking lipopolysaccharide-induced osteolysis through the suppression of NF-κB activity.
• Inducing apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells.
• Inducing MITF M isoform downregulation and senescence in MITF-M^high melanoma cells
• Agonist of the adiponectin receptor 2.
• Inhibition of mammalian thioredoxin reductase