In 1890 he made his major league debut in the National League with the Boston Beaneaters, and moved to the Brooklyn Bridegrooms in midseason; it would be the only time in his career that he played for a league champion. In he played in the American Association for the Louisville Colonels and Washington Statesmen; he then returned to the NL in, first with the Senators before going to the Pirates for most of the year. Donovan starred with the Pirates from through, notching six consecutive seasons batting.300 and serving as player-manager in and. The team was sold late in 1899, during a time when the league was contracting from twelve teams to eight; new owner Barney Dreyfuss brought in Fred Clarke to be manager, with Donovan being sent to the Cardinals. He played for St. Louis from -, sharing the league lead instolen bases in his first season, also managing the team in his last three seasons with them. By the end of the 1903 season he ranked among the NL's top ten career leaders in hits and at bats, though he would drop from among the leaders before his playing career ended. His 64 career double plays in the NL ranked one behind Jimmy Ryan's league record. He then served as player-manager for the American League's Washington Senators in 1904, his last season as a regular. In 1903, he broke Sam Thompson's major league record of 1401 games in right field; Willie Keeler passed him in 1906, before Donovan played his last several games and retired with a total of 1620. In, he became manager of the Brooklyn Superbas, and made his last few playing appearances that year, along with one more game at the end of the season. In a 17-season playing career, Donovan had 2256 hits, 1321 runs, 16 home runs and 738 runs batted in in 1824 games, along with 208 doubles and 75 triples. Donovan collected 302 stolen bases from 1890 to 1897, and 216 more after the statistic was revised to its modern definition in 1898.
Post-playing career
Donovan joined the Boston Red Sox as a scout in, and managed the team in and. As a major league manager, he compiled a 684-879 record in 11 seasons. He was also instrumental in bringing Babe Ruth to the Sox in through his acquaintance with one of the Xaverian Brothers who coached Ruth at a Baltimore orphans' home. Later he went to the International League, where he led Buffalo to pennants in and, and also managed Jersey City in 1921–22 and 1925–26. In 1929 and 1930, Donovan managed the Orleans town team in the Cape Cod Baseball League. In 1930 one of his charges at Orleans was future New York Yankees legend Red Rolfe. In a 1930 old-timers' game at Braves Field in Boston, Donovan had a pinch hit single, at the age of 65. He finished out his career coaching High School baseball at Phillips Academy in Andover, where he coached the future 41st President, George H.W. Bush. Donovan died at the age of 88 in Lawrence, Massachusetts, on Christmas Day 1953, and is interred at St. Mary Cemetery in Lawrence.
Honors
In the Irish Baseball League, the annual award for best batter is named "The Patsy Donovan Batting Champion Award".