In 1990, Marshall had a guest role as Iris West, the love interest of Flash in the pilot episode on the short-lived Flash. In 1991, she guest-starred on Superboy with a young Clark Kent before he called himself Superman, playing the villainous Christina Riley, a woman who is, in secret, a werewolf. Both series are part of DC Comics media. In 1992, Marshall had a three-episode guest role on The Wonder Years and later guest-starred on shows such as Seinfeld, Nash Bridges, Grapevine and '. Later in 1992, she starred in the movie ' as Terri. In 1994, she got her first sitcom role on Wild Oats. In 1995, Marshall starred in the science fiction cult classicW.E.I.R.D. World, directed by William Maloneas, as Dr. Abby O'Reardon, an evil scientist who rejuvenates her boss and is bent in turning grown men into babies. After a few years in B movies, Marshall gained a role on 1997's Chicago Sons. In the same year, she landed a recurring role on Spin City and starred with Bette Midler and Dennis Farina in the film That Old Feeling, where her character fell in love with one played by Danny Nucci. Marshall has also been cast in several pilots that were not picked up, including the Elizabeth Lackey series Cooking Lessons and Rob Thomas's Sticks. Marshall also was on Rob Thomas's Cupid, premiering in 1998. It featured her as Dr. Claire Allen, a psychiatrist supervising a man named Trevor who thinks he is Cupid. Marshall then joined David E. Kelley's Snoops about an unconventional detective agency. In 2000, Marshall returned to television screens: first with a three-episode guest appearance as a porn star and love interest for Jeremy on Aaron Sorkin's Sports Night, and then in Cursed. In 2002, she guest starred on Just Shoot Me! as the daughter of Nina Van Horn. Hidden Hills was an offbeat comedy about three families in suburbia. Marshall also had in a secondary role in the Steve Martin-Bonnie Hunt remake of Cheaper by the Dozen and a cameo appearance in Break a Leg, which starred her husband Danny Nucci. In 2004, Marshall appeared in an episode of Alicia Silverstone's Miss Match, but the series was cancelled before it aired. In October, she had a four-episode role in Veronica Mars,, and she reprised the role toward the end of season two. Marshall's next main role came in the sitcom Out of Practice. In 2007, Marshall appeared in the Showtime series Californication. She also was seen in the FX series Nip/Tuck as an insecure actress who dated Dr. Sean McNamara. In 2008, Marshall joined the crime drama Shark as a recurring character. Marshall starred on the CBS sitcom Gary Unmarried. She and Jay Mohr played a divorced couple sparring while trying to be loving parents to their two kids. The show was her first to be picked up for a second season. Marshall had a guest role in the hit drama House, playing Julia, sister of Lisa Cuddy. In 2012, Marshall guest starred in an episode of . She played the role of Kathy Veck, owner of an oil company. In 2013, Marshall guest starred in two episodes of Two and a Half Men as Alan Harper's transgender girlfriend Paula.
Personal life
Marshall is from Rockville, Maryland. She has been married to fellow actor Danny Nucci since 2003, and they have a daughter. She is the sister of Virginia politician Bob Marshall, who became widely known for proposing a "bathroom bill" before his defeat by transgender candidate Danica Roem in the November 2017 state election. Paula Marshall attributed his defeat to "karma" for his "homophobic" acts.