Pelvic organ prolapse


Pelvic organ prolapse is characterized by descent of pelvic organs from their normal positions. In women, the condition usually occurs when the pelvic floor collapses after gynecological cancer treatment, childbirth or heavy lifting.
In men, it may occur after the prostate gland is removed. The injury occurs to fascia membranes and other connective structures that can result in cystocele, rectocele or both. Treatment can involve dietary and lifestyle changes, physical therapy, or surgery.

Types

Pelvic organ prolapses are graded either via the Baden–Walker System, Shaw's System, or the Pelvic Organ Prolapse Quantification System.

Shaw's System

Anterior wall
Posterior wall
Uterine prolapse

POP-Q

StageDescription
0No prolapse anterior and posterior points are all −3 cm, and C or D is between −TVL and − cm.
1The criteria for stage 0 are not met, and the most distal prolapse is more than 1 cm above the level of the hymen.
2The most distal prolapse is between 1 cm above and 1 cm below the hymen.
3The most distal prolapse is more than 1 cm below the hymen but no further than 2 cm less than TVL.
4Represents complete procidentia or vault eversion; the most distal prolapse protrudes to at least cm.

Management

Vaginal prolapses are treated according to the severity of symptoms.

Non surgical

With conservative measures (changes in diet and fitness, Kegel exercises, pelvic floor physical therapy.
With a pessary, a rubber or silicone rubber device fitted to the patient which is inserted into the vagina and may be retained for up to several months. Pessaries are a good choice of treatment for women who wish to maintain fertility, are poor surgical candidates, or who may not be able to attend physical therapy. Pessaries require a provider to fit the device, but most can be removed, cleaned, and replaced by the woman herself. Pessaries should be offered to women considering surgery as a non-surgical alternative.

Surgery

With surgery. Surgery is used to treat symptoms such as bowel or urinary problems, pain, or a prolapse sensation. A 2016 Cochrane review concluded that evidence does not support the use of transvaginal surgical mesh compared with native tissue repair for anterior compartment prolapse owing to increased morbidity. Safety and efficacy of many newer meshes is unknown. The use of a transvaginal mesh in treating vaginal prolapses is associated with side effects including pain, infection, and organ perforation. According to the FDA, serious complications are "not rare." A number of class action lawsuits have been filed and settled against several manufacturers of TVM devices.
Compared to native tissue repair, transvaginal permanent mesh probably reduces women's perception of vaginal prolapse sensation and probably reduces the risk of recurrent prolapse and of having repeat surgery for prolapse. On the other hand, transvaginal mesh probably has a greater risk of bladder injury and of needing repeat surgery for stress urinary incontinence or mesh exposure.

Epidemiology

Genital prolapse occurs in about 316 million women worldwide as of 2010.

Research

To study POP, various animal models are employed: non-human primates, sheep, pigs, rats, and others.