| Week | Player | Team | Position | Key statistics and notes |
| 1 | Dexter McCluster | Kansas City Chiefs | Return specialist | 94-yard punt return touchdown |
| 2 | Jahvid Best | Detroit Lions | Running back | 232 yards from scrimmage, 3 touchdowns |
| 3 | Tony Moeaki | Kansas City Chiefs | Tight end | 44 yards, 1 touchdown |
| 4 | Sam Bradford | St. Louis Rams | Quarterback | 23 of 41, 289 yards, 1 TD, and 1 INT |
| 5 | Max Hall | Arizona Cardinals | Quarterback | 17 of 27, 168 yards, and 1 INT |
| 6 | Chris Ivory | New Orleans Saints | Running back | 158 yards rushing, 17 yards passing |
| 7 | Dez Bryant | Dallas Cowboys | Wide receiver/Punt returner | 171 total yards, 3 touchdowns |
| 8 | Ndamukong Suh | Detroit Lions | Defensive tackle | 2 sacks, 4 tackles, 17-yard fumble return touchdown |
| 9 | Jacoby Ford | Oakland Raiders | Wide receiver | 148 receiving yards, 94-yard kickoff return touchdown |
| 10 | Tim Tebow | Denver Broncos | Quarterback | two touchdowns, one rushing and one passing |
| 11 | Bryan McCann | Dallas Cowboys | Punt returner | returned a punt 97 yards for a touchdown and had one tackle |
| 12 | Sam Bradford | St. Louis Rams | Quarterback | completed 22 of 37 passes for 308 yards and three touchdowns |
| 13 | Sean Lee | Dallas Cowboys | Linebacker | two interceptions, returning one for a 31-yard touchdown |
| 14 | Rob Gronkowski | New England Patriots | Tight end | five receptions for 43 yards and a touchdown |
| 15 | Aaron Hernandez | New England Patriots | Tight end | four receptions for 31 yards and two touchdowns |
| 16 | Tim Tebow | Denver Broncos | Quarterback | completed 16 of 29 passes for 308 yards, a touchdown, and an interception; 27 yards rushing, 1 rushing touchdown |
| 17 | Rob Gronkowski | New England Patriots | Tight end | six receptions for 102 yards and a touchdown |
| Week | Player | Team | Position | Key statistics and notes |
| 1 | Randall Cobb | Green Bay Packers | Wide receiver | 2 receptions, 35 yards, 1 touchdown; record-tying 108-yard kickoff touchdown return |
| 2 | Denarius Moore | Oakland Raiders | Wide receiver | 5 receptions, 146 yards, 1 touchdown |
| 3 | Stefen Wisniewski | Oakland Raiders | Offensive guard | Helped lead key blocks for a Raiders' ground game that got 234 yards of offense |
| 4 | Cam Newton | Carolina Panthers | Quarterback | 27 of 46, 374 yards, 1 TD, 1 INT; 8 rushes, 35 yards, 2 TDs |
| 5 | Aldon Smith | San Francisco 49ers | Linebacker | 2 tackles, 2 sacks |
| 6 | Aldon Smith | San Francisco 49ers | Linebacker | 4 tackles, 2 sacks, 1 safety, 1 forced fumble |
| 7 | DeMarco Murray | Dallas Cowboys | Running back | Single-Game Franchise Record 253 rushing yards, 1 TD |
| 8 | Marcell Dareus | Buffalo Bills | Defensive end | 4 tackles, 2.5 sacks |
| 9 | Andy Dalton | Cincinnati Bengals | Quarterback | 22 of 39, 217 yards, 3 TD |
| 10 | Denarius Moore | Oakland Raiders | Wide receiver | 5 receptions, 123 yards, 2 touchdowns |
| 11 | Torrey Smith | Baltimore Ravens | Wide receiver | 6 receptions, 165 yards, 1 touchdown |
| 12 | Andy Dalton | Cincinnati Bengals | Quarterback | 21 of 31, 270 yards, 1 TD |
| 13 | Colin McCarthy | Tennessee Titans | Linebacker | 9 tackles, 1 forced fumble, 2 fumble recoveries |
| 14 | T.J. Yates | Houston Texans | Quarterback | 26 of 44, 300 yards, 2 TD, 1 INT |
| 15 | Cam Newton | Carolina Panthers | Quarterback | 13 of 23, 149 yards, 2 TD; 7 carries, 55 yards |
| 16 | Cam Newton | Carolina Panthers | Quarterback | 12 of 17, 171 yards, 3 TD; 6 carries, 65 yards, 1 TD |
| 17 | Sterling Moore | New England Patriots | Cornerback | 1 assisted tackle, 2 interceptions; includes a 21-yard INT return for a TD |
| Week | Player | Team | Position | Key statistics and notes |
| 1 | Robert Griffin III | Washington Redskins | Quarterback | 19 of 26, 320 yards, 2 TD; 9 carries, 42 yards |
| 2 | Trent Richardson | Cleveland Browns | Running back | 19 carries, 109 rushing yards, 1 TD; 4 receptions, 36 receiving yards, 1 TD |
| 3 | Andrew Luck | Indianapolis Colts | Quarterback | 22 of 46, 313 yards, 2 TD, 1 INT; 4 carries, 50 rushing yards |
| 4 | Robert Griffin III | Washington Redskins | Quarterback | 26 of 35, 323 yards; 8 carries, 36 yards, 1 TD |
| 5 | Andrew Luck | Indianapolis Colts | Quarterback | 31 of 55, 362 yards, 2 TD, 1 INT |
| 6 | Robert Griffin III | Washington Redskins | Quarterback | 17 of 22, 182 yards, 1 TD; 8 carries, 138 yards, 2 TD |
| 7 | Alfred Morris | Washington Redskins | Running back | 22 carries, 120 yards |
| 8 | Andrew Luck | Indianapolis Colts | Quarterback | 26 of 38, 297 yards, 1 TD, 0 INT |
| 9 | Doug Martin | Tampa Bay Buccaneers | Running back | 25 carries, 251 rushing yards, 4 TD, 4 receptions, 21 yards |
| 10 | Russell Wilson | Seattle Seahawks | Quarterback | 12 of 19, 188 yards, 2 TD; 7 carries, 34 yards |
| 11 | Robert Griffin III | Washington Redskins | Quarterback | 14 of 15, 200 yards, 4 TD; 12 carries, 84 yards, 158.3 passer rating |
| 12 | Robert Griffin III | Washington Redskins | Quarterback | 20 of 28, 311 yards, 4 TD, 1 INT; 7 carries, 29 yards |
| 13 | Robert Griffin III | Washington Redskins | Quarterback | 13 of 21, 163 yards, 1 TD; 5 carries, 72 yards |
| 14 | Alfred Morris | Washington Redskins | Running back | 23 carries, 129 yards, 1 TD, 1 fumble |
| 15 | Kirk Cousins | Washington Redskins | Quarterback | 26 of 37, 329 yards, 2 TD, 1 INT |
| 16 | Robert Griffin III | Washington Redskins | Quarterback | 16 of 24, 198 yards, 2 TD, 1 INT |
| 17 | Alfred Morris | Washington Redskins | Running back | 33 carries, 200 yards, 3 TD |
| Week | Player | Team | Position | Key statistics and notes |
| 1 | Caleb Sturgis | Miami Dolphins | Kicker | 3/3 Field Goals, 2/2 Extra Points |
| 2 | EJ Manuel | Buffalo Bills | Quarterback | 27 of 39, 296 yards, 1 TD, 1 INT; 4 carries, 13 rushing yards |
| 3 | Giovani Bernard | Cincinnati Bengals | Running back | 10 carries, 50 rushing yards, 1 TD; 4 receptions, 49 receiving yards |
| 4 | Kiko Alonso | Buffalo Bills | Linebacker | 5 combined tackles, 2 interceptions |
| 5 | Geno Smith | New York Jets | Quarterback | 16 of 20, 199 yards, 3 TD; 3 carries, 21 rushing yards |
| 6 | Keenan Allen | San Diego Chargers | Wide receiver | 9 receptions, 107 yards, 1 TD |
| 7 | D. J. Fluker | San Diego Chargers | Offensive tackle | Offense produced season high 158 rushing yards |
| 8 | Sio Moore | Oakland Raiders | Linebacker | 6 combined tackles, 1.5 sacks |
| 9 | Eddie Lacy | Green Bay Packers | Running back | 22 carries, 150 rushing yards, 1 TD |
| 10 | Tavon Austin | St. Louis Rams | Wide receiver | 2 receptions, 138 yards, 2 TDs |
| 11 | Matt McGloin | Oakland Raiders | Quarterback | 18 of 32, 197 yards, 3 TDs |
| 12 | Keenan Allen | San Diego Chargers | Wide receiver | 9 receptions, 124 yards |
| 13 | Zach Ertz | Philadelphia Eagles | Tight end | 5 receptions, 68 yards, 2 TDs |
| 14 | Marlon Brown | Baltimore Ravens | Wide receiver | 7 receptions, 92 yards, 1 TD |
| 15 | Keenan Allen | San Diego Chargers | Wide receiver | 2 receptions, 29 yards, 2 TDs |
| 16 | Le'Veon Bell | Pittsburgh Steelers | Running back | 26 carries, 124 yards, 1 TD |
| 17 | Keenan Allen | San Diego Chargers | Wide receiver | 5 receptions, 89 yards |
