Shakes-Drayton came to prominence at the English Schools Championships where she set a UK junior record time in the 400 m hurdles. She made her first major international appearance at the 2006 World Junior Championships in Athletics where she finished eighth, achieving a new personal best of 57.52 seconds. She took the silver medal at the 2007 European Athletics Junior Championships with a time of 56.46 s, a national junior record in the event. Shakes-Drayton won the 400 m hurdles at the 2008 Olympic Games GB trials, but veteran Tasha Danvers was chosen to represent Great Britain instead, going on to win the bronze medal. Despite the non-selection, Shakes-Drayton was considered to be a medal prospect for the next Olympics in 2012. At the 2009 British Championships in Birmingham, she finished second in the 400 metres behind reigning world champion Christine Ohuruogu, setting a new personal best. Further success came on the junior circuit at the 2009 European Athletics U23 Championships, where set won the 400 m hurdles gold medal with a run of 55.26 seconds, another personal best. Having secured a place on the Great Britain team, she set her sights on the 2009 World Championships in Athletics, remarking: "I like people talking about me. It means I must be doing some things right. Now I have to live up to the hype because hype is pointless if you don't live up to it.". She ran at the 2009 World Championships in Athletics in Berlin and reached the semi-finals of the competition. However, she finished seventh in the race with a time of 57.57 seconds and did not compete in the final. She ran a personal best of 54.91 seconds for the 400 m hurdles to win at the Memorial Primo Nebiolo in June 2010. In the absence of Tasha Danvers, Shakes-Drayton and Eilidh Child were the sole representatives for Great Britain at the 2010 European Athletics Championships. Shakes-Drayton finished 2nd in her heat, with a time of 55.35. She then finished 3rd in her semi-final to qualify for the final in a new personal best of 54.73. In the final she finished third to win the bronze medal with a new personal best of 54.18. At the 2012 London Grand Prix, the final Diamond League meeting prior to the 2012 London Olympic Games, Shakes-Drayton recorded another personal best for the 400m hurdles of 53.77, a time that put her second in the world rankings for the year and also made her the second fastest British athlete of all time in the event behind only Sally Gunnell. However, in the Olympic 400m hurdles she was unable to reach the final, finishing third in her semi-final heat. She was also part of the GB 4 × 400 m relay team which finished fifth in the final of that event. At the 2013 European Athletics Indoor Championships in Gothenburg, Shakes-Drayton went on to win gold in the Women's 400m final with a Personal Best of 50.85 ahead of another Great Britain runner Eilidh Child. She was also part of the Women's 4 × 400 m team along with Eilidh Child, Shana Cox and Christine Ohuruogu which won gold at the same championships.
