Dr. Wipf joined the University of Pittsburgh Department of Chemistry in 1990, and has remained there ever since. He became a full professor in 1997, and became a Distinguished University Professor of Chemistry in 2004. In 2001, he was appointed Professor of Pharmaceutical Sciences in the School of Pharmacy. He is director of the university's Center for Chemical Methodologies & Library Development. He has been an Adjunct Professor at Duke University's Department of Chemistry since 2002. His research interests center on the discovery of new drugs, including the total synthesis of natural products, organometallic and heterocyclic chemistry, and medicinal chemistry. He serves on many advisory and editorial boards in the fields of chemistry and pharmaceuticals.
Publications
Peter Wipf is the author or coauthor of over 500 academic publications. Seventy-five of his original research publications have been cited over 100 times in the literature, including:
Wipf, P.; Miller, C. P., "A new synthesis of highly functionalized oxazoles." J. Org. Chem.1993, 58, 3604.
Wipf, P.; Cunningham, A., "A solid phase protocol of the Biginelli dihydropyrimidine Synthesis suitable for combinatorial chemistry." Tetrahedron Lett.1995, 36, 7819.
Wipf, P.; Lim, S., "Total synthesis of the enantiomer of the antiviral marine natural product hennoxazole A." J. Am. Chem. Soc.1995, 117, 558.
Wipf, P.; Kim, Y.; Goldstein, D. M., "Asymmetric total synthesis of the Stemona alkaloid -stenine." J. Am. Chem. Soc.1995, 117, 11106.
Studer, A.; Jeger, P.; Wipf, P.; Curran, D. P., "Fluorous synthesis: Fluorous protocols for the Biginelli and Ugi multi-component condensations." J. Org. Chem.1997, 62, 2917.
Wipf, P.; Ribe, S., "Zirconocene-zinc transmetalation and in situ catalytic asymmetric addition to aldehydes." J. Org. Chem.1998, 63, 6454.
Kondru, R. K.; Wipf, P.; Beratan, D. N., "Atomic contributions to the optical rotation angle as a quantitative probe of molecular chirality." Science1998, 282, 2247.
Phillips, A. J.; Uto, Y.; Wipf, P.; Reno, M. J.; Williams, D. R., "Synthesis of functionalized oxazolines and oxazoles with DAST and Deoxo-Fluor." Org. Lett.2000, 2, 1165.
Lazo, J. S.; Aslan, D. C.; Southwick, E. C.; Cooley, K. A.; Ducruet, A. P.; Joo, B.; Vogt, A.; Wipf, P., "Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25." J. Med. Chem.2001, 44, 4042.
Ihle, N. T.; Williams, R.; Chow, S.; Chew, W.; Berggren, M. I.; Paine-Murrieta, G.; Minion, D. J.; Halter, R. J.; Wipf, P.; Abraham, R.; Kirkpatrick, L.; Powis, G., "Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling." Mol. Cancer Therap.2004, 3, 763.
Honors and awards
Among many other honors and awards, Dr. Wipf is a:
