Phenylacetyl-CoA
Phenylacetyl-CoA is a form of acetyl-CoA formed from the condensation of the thiol group from Coenzyme A with the carboxyl group of phenylacetic acid.
Its molecular-weight is 885.7 g/mol. and IUPAC name is S-methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 2-phenylethanethioate. It is formed via the actions of Phenylacetate—CoA ligase.
Phenylacetyl-CoA is often produced via the reduction of ATP to AMP and the conversion of phenylacetate and CoA to diphosphate and Phenylacetyl-CoA.
This reaction is catalyzed by Phenylacetate-CoA ligase.
Phenylacetyl-CoA combines with water and quinone to produce phenylglyoxylyl-CoA and quinol via a Phenylacetyl-CoA dehydrogenase reaction acting as an oxidoreductase.
Phenylacetyl-CoA inhibits choline acetyltransferace acting as a neurotoxin. It competes with Acetyl-CoA.
