Arriving in Naples at the age of eighteen, he devoted himself to the study of law, but his legal pursuits were much surpassed in importance by his literary works. He devoted twenty years to the composition of his great work, the Storia civile del regno di Napoli, ultimately published in 1723. In his account of the rise and progress of the Neapolitan laws and government, he warmly espoused the side of the civil power in its conflicts with the Roman Catholic hierarchy.
His merit lies in the fact that he was the first to deal systematically with the question of Church and State, and the position taken by him, and the manner in which that position was assumed, gave rise to a lifelong conflict between Giannone and the Roman Catholic Church. Despised by the mob of Naples, and excommunicated by the archbishop's court, he was forced to leave Naples and settled in Vienna, Austria. Meanwhile, the Roman Inquisition had attested the value of his history by putting it on the Index Librorum Prohibitorum.
In Vienna the favor of the Emperor Charles VI and of many leading personages at the Austrian court obtained for him a pension and other facilities for the prosecution of his historical studies. Of these the most important result was Il Triregno, ossia del regno del cielo, della terra, e del papa.
On the transfer of the Neapolitan crown to Charles of Bourbon, Giannone gave up his Austrian pension and relocated to Venice, hoping to find service with the new Neapolitan monarchy. But denied a passport to Naples, he remained in Venice where he was, at first, favorably received. The post of consulting lawyer to the republic, in which he might have continued the type of service that Fra Paolo Sarpi had exemplified in previous centuries, was offered to him, as well as that of professor of public law in Padua. He declined both offers. Unhappily there arose a suspicion that his views on maritime law were not favorable to the pretensions of Venice, and notwithstanding all his efforts to dissipate this suspicion, the distrust of Giannone together with clerical intrigues, led to his expulsion from the Republic.
On 23 September 1735 Giannone was seized and conveyed to Ferrara. He wandered under an assumed name for three months through Modena, Milan and Turin, he at last reached Geneva, where he enjoyed the friendship of the most distinguished citizens, and was on excellent terms with the great publishing firms. But he was induced to visit a Catholic village within Sardinian territory, in order to hear mass on Easter day. Giannone was there kidnapped by the agents of the Sardinian government, conveyed to the castle of Miolans and transferred to Ceva and Turin.
Turin
In the fortress of Turin he remained imprisoned for the last twelve years of his life, although part of his time was spent in composing a defence of the Sardinian interests as opposed to those of the papacy. He was also forced to sign a retraction of statements in his books that were most obnoxious to the Vatican. After his recantation his detention was made less severe and he was allowed many alleviations. In spite of his stay in a Turin prison he endured the sufferings in the manner of a confessor and martyr in the cause of what he deemed historical truth.
Style
Giannone's style as an Italian writer has been pronounced to be below a severe classical model; he is often inaccurate as to the facts, for he did not always work from original authorities, and he was sometimes guilty of unblushing plagiarism. But his very ease and freedom have helped to make his volumes more popular than many works of greater classical renown. In England the just appreciation of his labors by Edward Gibbon, and the ample use made of them in the later volumes of The Decline and Fall of the Roman Empire, early secured him his rightful place in the estimation of English scholars.