Sambi was born in Sogliano al Rubicone, Italy, on 27 June 1938. He spoke Italian, English, French and Spanish. He was ordained to the priesthood for the Diocese of San Marino-Montefeltro on 14 March 1964 and earned degrees in theology and canon law. At the Diocesan Seminary in Pennabilli he was responsible for priestly formation and then became Vice Rector. He entered the diplomatic service of the Holy See in 1969, serving first at the nunciature in Cameroon. He moved to the Apostolic Nunciature in Jerusalem on 19 July 1971, and then to the Apostolic Nunciatures in Cuba in 1974, Algeria in 1978, Nicaragua in 1979, Belgium in 1981, and India in May 1984 with the rank of counselor. In Nicaragua, he was named charge d'affaires just after the leftist Sandinistas under Daniel Ortega came to power and mediated between the Catholic bishops who opposed priests' participation in the government and priests who held prominent government offices in the socialist government. On 10 October 1985, Pope John Paul II named him pro-nuncio to Burundi and titular archbishop of Bellicastrum. In 1991 he was made pro-nuncio to Indonesia. On 6 June 1998 he was named to several positions concurrently: Nuncio to Israel and to Cyprus and Apostolic Delegate in Jerusalem and Palestine. When the Basilica of the Nativity in Bethlehem became the center of a stalemate between Palestinian Israeli forces, he negotiated a peaceful resolution. He also criticized Israel's construction of a wall to separate the Palestinian territories from Israel. In March 2003 he warned that Palestinian plans for self-government made no allowance for the practice of religions other than Islam. He also criticized the anti-Semitism found in Palestinian schoolbooks and successfully campaigned for Italy to discontinue support for educational initiatives that used such works. He campaigned for a special status for Jerusalem that would allow it to serve as the center of several major religions. In 2005, he complained that Israel was failing to implement agreements reached with the Holy See over church properties and the treatment of Catholic Arabs in Jerusalem more than a decade earlier. Pope Benedict XVI named Sambi the Apostolic Nuncio to the United States and Permanent Observer of the Holy See to the Organization of American States on 17 December 2005. He was installed in early 2006. He toured the damage left by Hurricane Katrina during the summer of 2006, shortly after his appointment. During Pope Benedict's April 2008 visit to the U.S., Sambi accompanied the Pope and hosted him at the apostolic nunciature, where the Pope held a historic private meeting with five victims of clergy sexual abuse. As nuncio, beginning in 2007, he was tasked with and had little success in enforcing restrictions that Pope Benedict XVI placed on Cardinal Theodore McCarrick, Archbishop emeritus of Washington, because of reports of inappropriate sexual behavior. Sambi received an honorary doctorate from Regis University in Denver, Colorado, on 8 May 2011. He was the 2009 Living Stones Solidarity Award of the Holy Land Christian Ecumenical Foundation for his work in the Middle East. On 22 July 2011, Sambi underwent lung surgery and developed complications that required the use of assisted ventilation. On 27 July, he died Johns Hopkins Medical Center in Baltimore, apparently from complications relating to that surgery.
