Starting in the one-shot comicThe Amazing Spider-Man Super Special #1, Eddie Brock contemplates his relationship with the Venom symbiote after Venom's spawn Phage, Riot, Lasher, Agony, and Scream struggle to control themselves against their own symbiotes. While teamed with Spider-Man against a terrorist group, Brock realizes the symbiote is influencing him to kill. Spider-Man attempts to convince Eddie to abandon the symbiote by blaming it for Brock's insanity. Brock forces the symbiote to leave him, to allow him to think about the situation uninfluenced. Angry at being rejected, the symbiote unleashes a powerful, telepathic scream that draws a spaceship of other symbiotes to Earth. Continuing in the same issue, the symbiotes begin possessing random civilians and committing murders. Brock, believing his symbiote is to blame, teams with Spider-Man and the Scarlet Spider to investigate. They eventually discover the symbiotes are creating a massive machine out of stolen Earth components. The three engage the symbiotes but find themselves overwhelmed. Scarlet Spider is revealed to be wearing a symbiote, which drags all three through the machine. Following part 2 in the one-shot Spider-Man Super Special #1, the one-shot Venom Super Special #1, finds the three on another planet, a world conquered by the symbiotes, the machine revealed to be a teleporter. The symbiote that had bonded with the Scarlet Spider is revealed to be Venom, who again bonds with Brock. Venom conveys the history of the symbiotes as a race of creatures intent on taking over host bodies from other races in order to feel emotion. The Venom symbiote was considered an aberration for wanting to bond with a host instead of dominating them. Venom also reveals the symbiotes intend to conquer Earth next. Spider-Man, the Scarlet Spider and Venom escape through the teleporter to Earth, but are followed by the symbiote invasion force. The Spectacular Spider-Man Super Special #1 continues the story with a symbiote releasing from prison the serial killerCletus Kasady, unleashing the bonded symbiote that makes Kasady the supervillainCarnage. Carnage absorbs the second symbiote and becomes stronger as a result. Spider-Man, Scarlet Spider and Venom launch an assault against the symbiote invaders but are overwhelmed. As they are about to be defeated, Carnage appears, having grown to building-size proportions by consuming symbiotes. The conclusion in Web of Spider-Man Super Special #1 finds Carnage seeking out Venom to kill him. Spider-Man and Scarlet Spider fight Carnage while Venom attempts to create a more powerful telekinetic scream to subdue the symbiotes. Spider-Man and Scarlet Spider defeat Carnage and Brock fully bonds with his symbiote to create the necessary scream. The scream creates enough pain and despair that the symbiotes commit suicide. Venom decides he is content to be both Brock and the symbiote.
Planet of the Symbiotes is one of the two storylines that serves as the primary inspiration for the 2018 film Venom. Planet of the Symbiotes is adapted as the eighteenth Spec-Ops Mission of . Planet of the Symbiotes also served as the inspiration of Spider-Man: Maximum Venom.
