Plumbagin

Pharmacologic properties

• antimicrobial,
• antimalarial,
• anti-inflammatory,
• anticarcinogenic,
• cardiotonic,
• immunosuppressive,
• antifertility action,
• neuroprotective,
• anti-atherosclerosis effects.
• Plumbagin has been shown to induce cell cycle arrest and apoptosis in numerous cancer cell lines including melanoma, lung, breast and others. It triggers autophagy via inhibition of the Akt/mTOR pathway and induces G2/M cell cycle arrest and apoptosis in A549 cells through JNK-dependent p53 Ser15 phosphorylation. Promotes autophagic cell death in MDA-MB-231 and MCF-7 cells and inhibits Akt/mTOR signaling. Induces intracellular ROS generation in a PI 5-kinase-dependent manner.
• Plumbagin is also reported to have targeted anticancer activity against BRCA1 defective cancers. The cells that are having wild type BRCA1 may repair the damages caused by ROS induction due to plumbagin, where as cells defective in BRAC1 may not, as BRCA1 is involved in DNA damage repair activity.
• Positive inotropic activity
• Enzymatic spectrum of herbal plants Plumbago Linn.
• Bioactive spectra of plumbagin.
• Effect on root- knot nematode Meloidogyne spp.