Amedeo undertook primary school and the greater part of his secondary education at the Jesuit school Sint-Jan Berchmanscollege in Brussels, popular with Belgian aristocracy and royalty. He finished his secondary education at Sevenoaks School in Kent, England, between 2001 and 2004. He then spent a year in Belgium's Royal Military Academy. In September 2005, he began studies at the London School of Economics, where he graduated in 2008 with a BSc degree in Management, and took a sabbatical before entering professional life. From July 2009 to June 2012, Amedeo worked for Deloitte in New York City, first as a business analyst from July 2009 to June 2011, then as a management consultant in strategy and operations from July 2011 to June 2012. He then worked as a research analyst intern at Accumulus Capital Management, LLC from August through December 2012. During 2013 and 2014, Amedeo resumed his studies, obtaining an MBA degree at the Columbia Business School of Columbia University. He subsequently returned to Belgium, where he worked for McKinsey & Company in Brussels from September 2014 to September 2016. In January 2017, he began working at the Gutzwiller private bank in Basel, where his father is a partner.
In 1991, Amedeo obtained, along with his mother and younger siblings, succession rights to the Belgian throne. In 1993, his maternal grandfather acceded to the throne as King Albert II and he became third in Belgium's line of succession, following his uncle Prince Philippe, Duke of Brabant, and his mother. Upon Philippe's marriage in 1999, the prospect of Amedeo inheriting the throne substantially diminished, and the birth of a daughter and dynastic heir to Philippe in 2001 dropped his place in the order of succession down to fourth and eventually to seventh, following the birth of Philippe's other children. The abdication on 21 July 2013 of his grandfather King Albert II promoted him to sixth in line to the throne. Although an announcement of Amedeo's engagement was published on the Royal Family's website, no dynastic authorisation for his marriage was published prior to his wedding, as foreseen in Article 85 of the Belgian Constitution. Speculation in the media included a commentator on the military parade for La Une who, on 21 July 2014, alleged that no royal authorisation was announced because the prince intentionally chose not to request permission to marry, and therefore Amedeo was no longer deemed in the line of succession. In November 2015, a royal decree expressing King Philippe's retroactive permission for the marriage was gazetted in the Moniteur Belge.
Titles and styles
21 February 1986 – 2 December 1991: His Imperial and Royal Highness Archduke Amedeo of Austria-Este, Prince Royal of Hungary and Bohemia
2 December 1991 – 7 February 1996: His Imperial and Royal Highness Prince Amedeo of Belgium, Archduke of Austria-Este, Prince Royal of Hungary and Bohemia
7 February 1996 – present: His Imperial and Royal Highness Prince Amedeo of Belgium, Archduke of Austria-Este, Prince Royal of Hungary and Bohemia, Prince of Modena
All the children of Princess Astrid and Archduke Lorenz bear the title of "Prince of Belgium" by Belgian Royal Decree of 2 December 1991, which is distinct from their traditional Austro-Hungarian titles, i.e. "Archduke/Archduchess of Austria-Este, Prince Royal of Hungary".