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Propylnorapomorphine
N-n-Propylnorapomorphine
is an
aporphine
derivative
dopamine agonist
closely related to
apomorphine
. In
rodents
it has been
shown
to
produce
hyperactivity
,
stereotypy
,
hypothermia
,
antinociception
, and
penile erection
, among other
effects
. Notably, its effects on
locomotion
are
biphasic
, with
low
doses
producing
inhibition
and
catalepsy
and high doses resulting in
enhancement
of
activity
. This is
likely
due to
preferential
activation
of D
2
/D
3
autoreceptors
versus
postsynaptic
receptors
, the
latter
of which overcomes the former to
increase
postsynaptic
dopaminergic
signaling
only with high doses.