Pruszków was incorporated as a town in 1916 during World War I, although a village has existed there since the 16th century. The development of the town was aided by the construction of the Warsaw-Vienna Railway in the 19th century and the construction of the Elektryczna Kolej Dojazdowa, Poland's first electrified commuter train line, in 1927. A large psychiatric hospital opened in the outlying village of Tworki in 1891 and is still operating to this day. During the World War I, a battle between German and Russian forces took place in Pruszków on 12–18 October 1914. Despite the initial success of the German forces on 12 October, they were push-backed out of town after successful Russian counter-attack on 14th. An intense artillery fire by both sides caused severe damages to many buildings in Pruszków including train station, power plant, and two churches. In August 1915 Pruszków was taken by the German forces without a fight.
The city had a large Jewish population before the Nazi–Soviet Invasion of Poland. In 1940, the German occupation authorities established a Jewish ghetto in Pruszków, in order to confine its Jewish population for the purpose of persecution and exploitation. The ghetto was liquidated on January 31, 1941, when all its 1,400–3,000 inhabitants were transported in cattle trucks to Warsaw Ghetto, the largest ghetto in all of Nazi occupied Europe with over 400,000 Jews crammed into an area of. From there, most victims were sent to Treblinka extermination camp. During the 1944 Warsaw Uprising, the Nazis created a large transit camp in Pruszków on the site of the Train Repair Shops to intern the evacuees expelled from the capital. Around 550,000 Warsaw residents and approximately 100,000 more from its outskirts were incarcerated in the Durchgangslager 121 set up for this purpose. The SS and Gestapo segregated the victims before transport. Approximately 650,000 Poles passed through the Pruszków camp in August, September and October 1944. Approximately 55,000 were sent to concentration camps, including 13,000 to Auschwitz. They included people from a variety of social classes and occupations, in varying physical conditions, and of various ages from infants only a few weeks old to the elderly, aged 86 or more. In a few cases, these were also people of different ethnic backgrounds including Jews living on "Aryan papers." Following the Soviet westward offensive, on March 26, 1945, the 16 members of the Polish Underground Government were invited by the Russians for talks, to a house in Pruszków on Armii Krajowej Street. They were captured by the Soviet NKVD agents, transported to USSR, imprisoned, tortured and sentenced in Moscow during the so-called Trial of the Sixteen.
Post-war Poland
After World War II, Pruszków became one of Masovia's largest industrial centers. Due to its proximity to Warsaw, it is now home to several factories and companies, including Herbapol, Daewoo Electronics, L'Oréal Cosmetics as well as logistic centers. It is also an important sports center, with a sports gymnasium, soccer stadium and a cycling course. Former Polish president Bronisław Komorowski spent part of his childhood in Pruszków.