Hemky Madera as Pote Galvez, a former Vargas Cartel lieutenant who has since become one of Teresa Mendoza's strongest allies.
Gerardo Taracena as Cesar "Batman" Guemes, Don Epifañio Vargas's right-hand man.
Joaquim de Almeida as Don Epifañio Vargas, Camilla Vargas's husband, head of the Vargas Cartel, and a candidate for the governor of the Mexican state of Sinaloa.
Idalia Valles as Isabela Vargas, the daughter of Camila and Epifañio Vargas.
Alfonso Herrera as Javier Jimenez, a member of the Jimenez cartel and a mercenary willing to kill for the highest bidder. He is now an ally of Teresa Mendoza.
David Andrews as Judge Cecil Lafayette, an corrupted judge who looking the other way and is making things harder for Teresa's drug operation in New Orleans
Recurring
Molly Burnett as Kelly Anne Van Awken, a Dallas socialite who becomes part of Teresa's inner circle.
Ryan O'Nan as King George, a smuggler who helps Teresa build her empire.
Joseph T. Campos as Boaz Jimenez, a former cartel leader who now runs Teresa's operations in Sinaloa and Miami
Mark Consuelos as Teo Aljarafe, the first lawyer Camila Vargas employs while setting in motion her plan for independence.
Michel Duval as Enrique "Kique" Jiménez, son of Boaz Jimenez, and later fiancé of Isabela Vargas.
James Martinez as Gato Fierros, a lieutenant in the Vargas Cartel
Ximena Duque as Eva Buemeros, Epifanio's smart and ambitious young assistant
Paola Andino as Olivia Gutiérrez, a close friend of Isabela Vargas since their childhood. She introduces Isabela into the drug-fueled party lifestyle of a "narco-brat".
Armando Riesco as Pecas, the narco boss of La Comisión, a group trafficking in Arizona.
Chris Greene as Bobby Leroux, Marcel Dumas's right-hand man.
Pêpê Rapazote as Raul 'El Gordo' Rodriguez, a Cuban drug dealer based in Miami who partners with Teresa and Oksana.
Vera Cherny as Oksana Volkova, a Russian drug dealer based in Atlanta who partners with Teresa and El Gordo.
Bailey Chase as Eddie Brucks, a musician attempting to overcome his personal demons who crosses paths with Teresa.
Chelsea Tavares as Birdie, a New Orleans mixology whiz who works at Teresa's bar.
Sofía Lama as Emilia, Javier's girlfriend and Boaz's ex-fiancé.
David Bianchi as Manny, one of Teresa's New Orleans soldiers.
Alejandro Barrios as Chicho, one of Teresa's New Orleans soldiers.
Felipe Barrientos as The Charger, Camila Vargas's gang master.
Adolfo Alvarez as Tony Parra, Brenda's son and Teresa's godson.
Julian Silva as Tony Parra, Brenda's son and Teresa's godson.
Cory Hart as Detective Randall Greene, a corrupt New Orleans cop who is Judge Lafayette's right-hand man.
Derek Evans as Davis Lafayette, Judge Lafayette's emotionally fragile son.
Donald Paul as Cedric, the savvy and sly hit man gangster working for Marcel Dumas and sometimes the Queen.
Episodes
Reception
Critical response
Queen of the South first season received mixed to positive feedback from critics. On Rotten Tomatoes, it has a rating of 68%, based on 19 reviews, with an average rating of 6.18/10. The site's consensus reads: "Queen of the South enlivens an overdone premise with action and narrative vigor—and shows hints of intriguing potential." On Metacritic, the first season scored 59 out of 100, based on 16 critics, indicating "mixed or average reviews".