Repulsive guidance molecule B
Repulsive guidance molecule B, also known as DRAGON, is a bone morphogenetic protein co-receptor of the repulsive guidance molecule family. In humans this protein is encoded by the RGMB gene.Function
RGMB is a glycosylphosphatidylinositol -anchored member of the repulsive guidance molecule family and contributes to the patterning of the developing nervous system.
There is a potential association between RGMs and cancer bone metastasis, as RGMs coordinate bone morphogenetic protein signaling. RGMB may act as a negative regulator in vitro in breast cancer and prostate cancer through BMP signalling. Furthermore, aberrant expression of RGMs was indicated in breast cancer. The perturbed expression was associated with disease progression and poor prognosis.
