RNF19A
E3 ubiquitin-protein ligase RNF19A is an enzyme that in humans is encoded by the RNF19A gene.
The protein encoded by this gene contains two RING-finger motifs and an IBR motif. This protein is an E3 ubiquitin ligase that is localized in Lewy bodies, neuronal inclusions characteristic of Parkinson's disease. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1, which is an interacting protein of alpha-synuclein in neurons, and a major component of LB. Alternatively-spliced transcript variants encoding the same protein have been reported.
