Rodríguez Mercado was the first to practice Endovascular Neurosurgery in Puerto Rico since 1997. Currently he is Professor of Neurosurgery at the University of Puerto RicoSchool of Medicine and director of the Endovascular Neurosurgery Program of that institution. He also leads the same program at ASEM Stroke Medical Center and, since 2001, is the director of the Fellows Training Program in Neuroendovascular Surgery at the University of Puerto Rico School of Medicine. There, he has trained physicians from many countries in this specialty as well had lecture conferences in many countries and published papers in peer review journals. Rodríguez Mercado is a member of 15 international medical societies and has participated in several scientific research projects. Currently he is licensed to practice medicine in New York, Texas, Florida, Pennsylvania, and Puerto Rico. In 2010, after a year as Interim Chancellor at the University of Puerto Rico, Medical Sciences Campus, he was named Chancellor of the Medical Sciences Campus of The University of Puerto Rico. In January 2017, Ricardo Rosselló, Governor of Puerto Rico, appointed Rodríguez Mercado as Secretary of Health of Puerto Rico. In September 2017, he was appointed as Associate Professor of Surgery initially and them promoted on February 2019 to Adjunct Professor of Surgery at the Uniformed Services University of Health Sciences. On April 2019, was appointed Professor of Surgery at Ponce Health Sciences University as part of his academic and military career. Rodríguez Mercado is a Fellow of the American College of Surgeons and a Diplomate of the American Board of Neurological Surgeons.
On 12 January 2017, he was appointed as 22nd Secretary of Health of Puerto Rico by Governor Ricardo Rosselló. His tenure as Health Secretary was marred with criticism over the Health Department's handling of mayor emergencies which affected Puerto Rico such as Hurricane Irma, Hurricane Maria, the 2020 earthquakes and the agency's botched handling of the COVID-19 outbreak as well as questionable Health Department contracts given to people associated with the governor's political campaign.
COVID-19 Outbreak Response
As COVID-19 cases were increasing in other states and countries, Rodríguez Mercado seemingly downplayed the urgency of the situation stating that the probability of an COVID-19 outbreak in Puerto Rico was unlikely. As suspected COVID-19 cases on the island grew, the agency resisted performing tests and sending them to the Centers for Disease Control and Prevention by setting a high bar on whom the tests should be performed. In one particular instance, an island doctor managed to convince the agency to test a patient only after pleading with CBS reporter David Begnaud, after the Health agency denied requests to test his patient.
Resignation
On March 13, 2020, under public pressure and at the behest of governor Wanda Vázquez Garced, he immediately resigned to the position of Secretary of Health. His resignation came after the confirmation of several cases of COVID-19 on the island which included the case the agency had initially resisted on testing, as well as findings that the test samples were sent later than had been publicly announced, and that there had been documentation errors that caused subsequent delays in reporting. He was succeeded by interim secretary Concepción Quiñones de Longo.
Personal life
Rodríguez Mercado is married to medical technologist, Wanda Santiago Pimentel. He has one son.