The story takes place in the near future, and describes a young girl living in an institution that raised children in order to sell their organs on the blackorgan transplantmarket. Her original eyes were taken and she was rescued and outfitted with a pair of new X-Ray eyes by the underground doctor Black Jack and then adopted by a surgeon named Dr. Kasugano. Ten years later, Ray took up her mother's profession and become a well known and respected surgeon because of her unique abilities and sharp skill. After beginning work at a less-than-typical hospital, Ray is faced with bizarre cases that require her specials skills. In the second half of the series she begins to uncover details about the organization that removed her eyes and the whereabouts of the other children with whom she was raised. The storylines take up bioethical issues such as organ donation, human cloning and even reincarnation. Like its counterpart Black Jack 21, the show favors science-fiction elements in place of realism, with cases often resembling actual medical conditions but with fantastical elements added to heighten drama.
Characters
Main characters
Hospital characters
Numbers characters
"Numbers" are clones created by H Ring Man and are so-called because of numbers tattooed behind their right shoulders. In an effort to distinguish themselves they created names for themselves.
Other characters
Episode list
Cultural references
Because of copyright reasons, Black Jack was only alluded to as BJ and never seen fully in the original manga, but because the anime was produced by Osamu Tezuka's own studio he is able to appear fully in the anime and be referred to by his original name. In Black Jack 21, the sequel to the Black Jack anime, Black Jack was referred to as "BJ" by the assassins hell bent on killing him.
At the end of episode 12 and throughout episode 13 the bandage over Ray's damaged eye may be a visual reference to another famous anime character with the same name; being Rei Ayanami of Neon Genesis Evangelion, who appears several times with a bandage over her right eye. The two characters also share the same red-colored eyes and distant personalities, as well as some elements of their unique origins.