Kizer attended Euclid High School in Euclid, Ohio. He played for the Walsh Cavaliers from 2003 to 2006. He recorded 14 interceptions for the Cavaliers, returning five for touchdowns. He was named First Team All-American and First Team All-Conference his senior year. He was also named Second team All-Conference as a junior and First team All-Conference as a sophomore. He was inducted into the school's Wall of Fame as part of the class of 2015.
Kizer signed with the New York Jets on May 15, 2007 after going undrafted in the 2007 NFL Draft. He was released by the Jets on August 27, 2007.
Montreal Alouettes
Kizer was signed by the Montreal Alouettes on September 11, 2007. He was released by the Alouettes on October 7, 2008.
Green Bay Blizzard
Kizer played for the Green Bay Blizzard of the af2 during the 2009 season. He played in 17 games for the Blizzard, recording 65 tackles, four interceptions, 15 pass break-ups, one forced fumble, and two fumble recoveries. He was awarded Defensive Player of the Week honors in the American Conference Finals Game after sealing the victory with a game-ending interception.
Orlando Predators
Kizer played for the Orlando Predators from 2010 to 2011. He led the Arena Football League in interceptions with 12 his rookie year in 2010, earning First Team All-Arena honors. He set a new AFL record when he recorded 16 interceptions during the 2011 season. Kizer was also named First Team All-Arena for the second consecutive year.
Montreal Alouettes
Kizer was signed to the practice squad of the Montreal Alouettes on September 27, 2011. He was released by the Alouettes on October 6, 2011.
Hamilton Tiger-Cats
Kizer was signed to the practice squad of the Hamilton Tiger-Cats on October 15, 2011. He was released by the Tiger-Cats on November 2, 2011.
Philadelphia Soul
Kizer signed with the Philadelphia Soul on November 22, 2011. He earned Second Team All-Arena honors after recording 82 tackles and nine interceptions in 18 games with the Soul in 2013. He was named Second Team All-Arena for the second consecutive year after collecting 101.5 tackles and nine interceptions in 18 games in 2014.
Arizona Rattlers
On January 7, 2015, Kizer was assigned to the Arizona Rattlers.
New Orleans VooDoo
On March 23, 2015, Kizer, along with Allen Chapman, were traded to the New Orleans VooDoo in exchange for future considerations.
Los Angeles KISS
On May 25, 2015, Kizer was traded to the Los Angeles KISS for future considerations. He earned Second Team All-Arena honors for the third consecutive year after recording 87.5 tackles and five interceptions in 2015. He became a free agent after the 2015 season. On November 6, 2015, Kizer was assigned to the KISS for the 2016 season.
Qingdao Clipper
Kizer was selected by the Qingdao Clipper in the fourth round of the 2016 CAFL Draft. He is listed on the Clipper's roster for the 2018 season.
Cleveland Gladiators
On January 9, 2017, Kizer was assigned to the Cleveland Gladiators. On July 18, 2017, Kizer was placed on reassignment.
