Patterson studied fiction writing with Jesse Hill Ford at the University of Alabama at Birmingham; his first short story was published in the Atlantic Monthly; and his first novel, The Lasko Tangent, won an Edgar Allan Poe Award in 1979. Between 1981 and 1985, he published The Outside Man, Escape the Night, and Private Screening, which made the New York Times bestseller list in 1994. His first novel in eight years, Degree of Guilt, and Eyes of A Child, were combined into a four hour TV mini-series by NBC TV, called Degree of Guilt. Both were international bestsellers, and Degree of Guilt was awarded the French Grand Prix de Litterateur Policiere in 1995. The Final Judgment, Silent Witness, No Safe Place, and Dark Lady all became immediate international bestsellers, and in 2011 Silent Witness became a feature film on TNT. Protect and Defend, about the controversial nomination of the first woman to be Chief Justice, and her entanglement in an incendiary lawsuit regarding late-term abortion and parental consent, was a #1 New York Times bestseller and received a Maggie Award from Planned Parenthood for its treatment of issues regarding reproductive rights. In 2013, the London Guardian Literary Review named No Safe Place one of the 10 best works of fiction, nonfiction, or biography inspired by John F. Kennedy and the Kennedy assassination in the 50 years since his death. Balance of Power confronted one of America’s most divisive issues—gun violence—and was chosen by USA Today as its book of the month selection for November. Conviction focused on the law and politics of capital punishment. Exile dealt with the Israeli-Palestinian conflict and was nominated for South Africa’s leading literary award. The Race concerned a dramatic campaign for President, and Eclipse dealt with human rights, Africa, and the geopolitics of oil. The Spire was a novel of psychological suspense, and In the Name of Honor portrays a military court martial for murder, and a legal defense based on PTSD. The Devil’s Light is an exhaustively researched depiction of the world of espionage and the potential for nuclear terrorism, focused on an Al Qaeda plot to steal a nuclear bomb from Pakistan in order to destroy a major western city. Patterson’s twentieth novel, Fall From Grace, a family drama set on Martha’s Vineyard, became his sixteenth New York Times bestseller. Its prequel, Loss of Innocence, is a coming-of-age novel set in the tumultuous year of 1968. Its sequel, Eden In Winter, concluded the trilogy and marked Patterson's retirement as a novelist. In 2015, Patterson began devoting his time to political commentary. During the 2016 presidential campaign, Patterson was a contributing opinion writer for the Huffington Post, with a focus on politics and international affairs, as well as a guest commentator on television. His book about that campaign, "Fever Swamp", was published in January 2017. Between 2017 and 2019, he was a columnist for the Boston Globe and HuffPost. He is now a columnist for The Bulwark, writing longer essays on politics, law, public policy and geopolitics. Patterson has appeared on such shows as Today, Good Morning America, The CBS Morning Show, Fox News Sunday, Morning Joe, Inside Politics, Washington Journal, Buchanan and Press, Greta Van Susteren, Fox and Friends, and Hardball. Beyond his regular columns, his articles on politics, society, literature, law, and foreign policy have been published in the London Times, the Wall Street Journal, The Atlantic, USA Today, the Washington Post, the Los Angeles Times, the Boston Globe, the San Francisco Chronicle, FoxNews.com, Medium, and the San Jose Mercury News. A frequent speaker on political, geopolitical, legal, and social issues, in 2004 Patterson spoke at Washington, D.C. rallies in support of reproductive rights, and against gun violence, and has spoken about the Israeli-Palestinian dilemma at such forums as the National Press Club in Washington, D.C. and the World Affairs Council in Dallas. Patterson is a member of the Cosmos Club of Washington DC, and his papers are collected by Boston University. In 2012, Patterson received the Silver Bullet Award from the International Thriller Writers Association for his contributions to the wider community. Overall, the worldwide sales of Patterson's novels exceeds 25 million copies.
Personal life
Patterson has three sons and two daughters. He lives on Martha's Vineyard and Cabo San Lucas, Mexico with his wife, Nancy Clair.