List of highways numbered 351

• Arkansas Highway 351
• County Road 351 (Dixie County, Florida)
• County Road 351A (Dixie County, Florida)
• County Route 351 (Albany County, New York)
• Georgia State Route 351
• Illinois Route 351
• Japan National Route 351
• Kentucky Route 351
• Louisiana Highway 351
• Manitoba Provincial Road 351
• Maryland Route 351
• Muskogee Turnpike
• National Highway 351 (India)
• New York State Route 351
• New York State Route 351 (1931–1970s)
• Newfoundland and Labrador Route 351
• Oklahoma State Highway 351
• Oregon Route 351
• Pennsylvania Route 351
• Prince Edward Island Route 351
• Puerto Rico Highway 351
• Quebec Route 351
• State Route 351 (Virginia 1942)
• Tennessee State Route 351
• Texas State Highway 351
• Virginia State Route 351
• Wisconsin Highway 351
• Wyoming Highway 351