Hartsfield played for the Boston Braves between 1950 and 1952. In 265 career games, he had a.273 batting average, 13 home runs, and 59 runs batted in during his playing career.
In 1977, Hartsfield was hired as the first-ever manager of the expansion Toronto Blue Jays by the Jays' first general manager, Peter Bavasi, who had worked with him in the Dodger and Padre organizations. Hartsfield was quoted in 1997 that "the guys I managed the year before in Hawaii were probably a better team." Hartsfield led the Jays to a 54–107 record in the 1977 season. Notable games from the season include a 9–5 win against the Chicago White Sox on opening day and a 19–3 win against eventual division champions New York Yankees. The Jays finished the season 45.5 games behind the Yankees.
1978 season
The Jays improved slightly, finishing the season with a record of 59–103, although they still finished the season in last place. The Jays finished second to last in runs scored and earned run average.
1979 season
In 1979, Hartsfield led the Jays to a record of 53–109, their worst showing yet, and the worst showing of any American League team since 1966. Unpopular with the Blue Jays players, by August the team was in open revolt against Hartsfield, with players airing their grievances in the media on a near-daily basis. Having lost over 100 games in each of his three years as manager, and having been very publicly criticized by the Toronto sports media for apparently having lost control of the team, Hartsfield was let go at the conclusion of the 1979 season and replaced by Bobby Mattick. "This year, we should win 10 more games on attitude alone", enthused pitcher Mark Lemongello about the managerial change. In fact, the Jays improved by 14 games that year. This would be Hartsfield's only managerial job in Major League Baseball. He compiled a record of 166–318 in 484 games, giving Hartsfield the worst managerial winning percentage since World War II His teams finished last in the American League East Division in each of his three seasons.
Later career
Hartsfield managed in the Chicago Cubs organization in 1981, starting the season with the Triple-A Iowa Oaks and finishing with the Double-A Midland Cubs. Both teams ended up with losing records, as did the Triple-A Indianapolis Indians in 1983, which was Hartsfield's final management job.
Managerial record
Death
Hartsfield died from complications of liver cancer at his daughter's home in Ball Ground, Georgia, on January 15, 2011, aged 85.