The protein encoded by this gene is a member of the S100 family of proteinscontaining 2 EF-hand calcium-binding motifs. S100A11, also known as calgizzarin or 100C, is a small acidic protein. Along with all 13 members of the S100 family, are located as a cluster on chromosome 1q21. It was first found in 1989, and later isolated from chicken gizzard muscles. The protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Its high expression has been found in many tissues including lung, pancreas, heart, placenta, kidney, and low levels in skeletal muscle, liver, and brain tissue. S100A11 is implicated in membrane and cytoskeletar dynamics, vesicular transportation and processes of endo and exocytosis. It has been shown that S100A11 interacts with many cytoskeletal structures as tubulin, actin, intermediate filaments also with annexin I and annexin II. S100A11 is able to control reorganization of actin and it is important in forming protrusion by metastatic cells. It lacks enzymatic activity, it functions by binding to other proteins, it regulates activity of other enzymes. It is associated with cell cycle, growth, survival and apoptosis. It has been identified as dual growth mediator. Suppression of S100A11 by small interfering RNA caused cells to apoptosis, and overexpression of S100A11 has been found to inhibit apoptosis in tumor cells. Furthermore, the knock-down of S100A11 via siRNA reduces the sister-chromatid exchange and the viability of cells.
S100A11 in pathologies
and TNF-alpha induce the expression and release of S100A11 in chondrocytes in culture and exogenous S100A11 causes chondrocyte hypertrophy. S100A11 could play a role in maintaining low-grade inflammation in osteoarthritis and in its progression. Its cellular localization is associated with the regulation of cell growth and proliferation. This protein is normally found strictly in the nucleus, but appears in the cytoplasm in cancer cells. S100A11 was localized in the cytoplasm of resting human keratinocytesin vitro. It has been shown to interact with the RAGE receptor, which is also a receptor for other S100 proteins. It is associated with low or high production in many different types of cancers. Its overproduction has been found, for example, in breast, pancreas or colectal carcinoma and its levels can be used as clinical marker in these diseases. It has been shown that S100A11 enhances the recombination activity of human RAD51 in vitro. A knock-down leads to diffuse distribution of RAD54B.These finding suggest a potential role of S100A11 in the process of homologous recombination repair of double-strand breaks. Usually, S100A11 makes homodimeres, but it has been shown that S100A11 heterodimerizes with S100B and it also interacts with Nucleolin, and RAD54B.
