SEMA4A


Semaphorin-4A is a protein that in humans is encoded by the SEMA4A gene.

Function

SEMA4A is a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in guidance of axonal migration during neuronal development and in immune responses.

Clinical significance

A germline variant in SEMA4A has been demonstrated to confer risk for colorectal cancer type X.