SOCS2
Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.
This gene encodes a member of the STAT-induced STAT inhibitor, also known as suppressor of cytokine signalling, family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor, and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.Interactions
SOCS2 has been shown to interact with insulin-like growth factor 1 receptor and erythropoietin receptor.
