SOSTDC1


Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene.

Function

This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal, cystine, knot-like domain. This protein functions as a bone morphogenetic protein antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.