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SPINT2
Kunitz-type protease inhibitor
2
is an
enzyme inhibitor
that in humans is encoded by the
SPINT2
gene
.
SPINT2 is a
transmembrane protein
with two
extracellular
Kunitz domains
to inhibit
serine proteases
. This gene is a
presumed
tumor suppressor
by
inhibiting
HGF
activator which prevents the
formation
of
active
hepatocyte growth factor
.
Mutations
in SPINT2 could result in
congenital sodium diarrhea
.