The salience network is primarily anchored at the AI and dACC. The node in the AI corresponds with the dorsal-anterior division distinguished in meta analyses of task-positive network related neuroimaging studies. The AI and dACC are linked via a white matter tract along the uncinate fasciculus. The subcortical nodes have yet to be structurally linked to the AI and dACC, however both seed-based and resting-state studies have observed intrinsic connectivity of the cortical nodes, with subcortical nodes consisting of the sublenticularextended amygdala, the putamen, the dorsomedial thalamus, the ventral striatum, and the substantia nigra/ventral tegmental area. The salience network is also distinguished by distinct cellular components, including von Economo neurons in the AI/dACC. Cortico-striatal-thalamic loop circuits contribute to the salience network.
Function
While the function of the salience network is not exactly known, it has been implicated in the detection and integration of emotional and sensory stimuli, as well as in modulating the switch between the internally directed cognition of the default mode network and the externally directed cognition of the central executive network. Evidence that the salience network mediates a switch between the DMN and CEN comes from Granger causality analysis and studies utilizing transcranial magnetic stimulation. The timing of electrophysiological responses during the oddball task is consistent with interaction, as after the initial mismatch negativity response is transmitted "bottom-up" from sensory regions, a "top-down" signal localized to the AI and dACC occurs before a widespread evoked potential that corresponds to attentional shifting.
Pathophysiology
Dysfunction in the salience network have been observed in various psychiatric disorders, including anxiety disorders, post-traumatic stress disorder, schizophrenia, frontotemporal dementia, and Alzheimer's disease. The AI node of the salience network has been observed to be hyperactive in anxiety disorders, which is thought to reflect predictions of aversive bodily states leading to worrisome thoughts and anxious behaviors. In schizophrenia, both structural and functional abnormalities have been observed, thought to reflect excessive salience being ascribed to internally generated stimuli. In individuals with autism, the relative salience of social stimuli, such as face, eyes, and gaze, may be diminished, leading to poor social skills.
Nomenclature
The cingulo-opercular network has generally been equated with the salience network, but it may represent a distinct but adjacent network or a part of the SN. The CO may involve more dorsal areas, while the SN involves more ventral and rostral areas of the anterior insula and medial frontal cortex containing von Economo neurons. The CO is sometimes also referred to as the cingulo-insular network. The ventral attention network, also known as the ventral frontoparietal network or ventral attention system, has also been equated with the SN. The VAN involves the temporoparietal junction and the ventral frontal cortex and may represent a larger, more bilateral network with more of an external awareness role than the SN. It has been described as including the SN and CO, but it has also been described as a part of the salience network involving the more dorsal anterior insular cortex.
