Sasso was born in 1947 in Philadelphia, Pennsylvania. In her youth, she was very involved in her Philadelphia Reform congregation and began to consider entering the rabbinate at 16 years old, though she knew that such a role had never been open to women. During this period she studied at Gratz College.
Rabbinical school
In the fall of 1969, Sasso joined the Reconstructionist Rabbinical College's second class of rabbinical students. While in school, Sandy Eisenberg married her classmate, Dennis Sasso, making them the first rabbinical couple in Jewish history. As one of the few women rabbinical students, Sasso naturally became a leader in defining women's changing roles within Judaism. Sasso holds title to many firsts as a female rabbi.
Rabbinical life
Sasso served as rabbi of the Manhattan Reconstructionist Congregation and, from 1977 until 2013, as rabbi along with her husband at the congregation Beth-El Zedeck in Indianapolis, making the Sassos the world's first couple to serve jointly as rabbis. Sasso appeared in a 2005 documentary, titled And the Gates Opened: Women in the Rabbinate, which features stories of and interviews with her, rabbi Sally Priesand, and rabbi Amy Eilberg. On December 6, 2010, at Temple Reyim in Newton, Massachusetts, Sandy Eisenberg Sasso met for the first time with Sally Priesand, the first Reform female rabbi, Amy Eilberg, the first Conservative female rabbi, and Sara Hurwitz, considered by some to be the first Orthodox female rabbi. They and approximately 30 other women rabbis lit Chanukah candles and then spoke about their experiences in an open forum. On June 3, 2012, Priesand, Sasso, Eilberg, and Hurwitz met again, this time at Monmouth Reform Temple at a celebration honoring the four first women rabbis to be ordained in their respective movements, and the 40th anniversary of Priesand's ordination. In May 2013, Sasso retired as senior rabbi of Beth-El Zedeck.
Adam and Eve's First Sunset: God's New Day, illustrated by Joani Keller Rothenberg, Jewish Lights Publishing, 2003.
Abuelita's Secret Matzahs, Emmis Books, 2005.
Butterflies under Our Hats, Paraclete Press, 2006.
The Shema in the Mezuzah: Listening to Each Other, Jewish Lights Publishing, 2012.
Regina Persisted: An Untold Story, illustrated by Margeaux Lucas, Apples & Honey Press, 2018.
Other works
Call Them Builders: A Resource Booklet about Jewish Attitudes and Practices on Birth and Family Life, Reconstructionist Federation of Congregations and Havurot, 1977.
The Voices of Children, Co-editor with Siddur Kol HaNoar, Reconstructionist Press, 2005.
God's Echo – Exploring Scripture with Midrash, Paraclete Press, 2010.
"How Jewish Women Have Come to Read the Bible: The Creating of Midrash" in The Sacred Calling: Four Decades of Women in the Rabbinate, CCAR Press, 2016.
Helen Keating Ott Award for Outstanding Contribution to Children's Literature, 2004.
National Jewish Book Award in the Illustrated Children's Book category for The Shema in the Mezuzah: Listening to Each Other, 2012. Illustration by Joani Keller Rothenberg.