Sean O'Brien

• Come (American band)
• Sean C. O'Brien
• Sean O'Brien (Ohio politician)
• Sean O'Brien (ice hockey)
• Sean O'Brien (labor leader)
• Sean O'Brien (musician)
• Sean O'Brien (windsurfer)
• Sean O'Brien (writer)
• Sean O'Bryan
• Seán O'Brien (Cork hurler)
• Seán O'Brien (Gaelic footballer)
• Seán O'Brien (Tipperary hurler)
• Seán O'Brien (rugby union, born 1987)
• Seán O'Brien (rugby union, born 1994)
• Shaun O'Brien
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