Second Oommen Chandy ministry
The United Democratic Front government led by Oommen Chandy sworn in on 18 May 2011. Seven of the total 20 members of the Cabinet took office on 18 May and the rest sworn in on 23 May after completing discussion with member parties of the UDF.
Ministers
| Minister | Ministry | Constituency | District | Party | |
| 1 | Oommen Chandy | Chief Minister, Minister for General Administration, Finance, State Treasury, Taxes & Duties, Excise, Fisheries, Port, Law and Housing, All India Services, Science and Technology, Scientific Institutes, Personnel and Administrative Reforms, Elections, Integration, Sainik Welfare, Distress Relief, State Hospitality, Inter State River Waters, Administration of Civil and Criminal Justice and subjects not mentioned elsewhere | Puthuppally | Kottayam | INC |
| 2 | Ramesh Chennithala | Minister for Home Affairs, Vigilance, Jail and Fire & Rescue | Haripad | Alappuzha | INC |
| 3 | P. K. Kunhalikutty | Minister for Industries, IT, Trade & Commerce, Mining & Geology and Wakf & Haj Affairs | Vengara | Malappuram | IUML |
| 4 | Thiruvanchoor Radhakrishnan | Minister for Forests, Wild Life Protection, Environment, Sports, Kerala State Film Development Corporation, Kerala State Chalachitra Academy, Kerala Cultural Workers Welfare Fund Board, Road Transport, Motor Vehicles and Water Transport | Kottayam | Kottayam | INC |
| 5 | Aryadan Muhammed | Minister for Electricity, Railways, Post and Telegraph, Pollution Control. | Nilambur | Malappuram | INC |
| 6 | K. C. Joseph | Minister for Information & Public Relations, Rural Development, Cultural affairs, NORKA and Dairy | Irikkur | Kannur | INC |
| 7 | Shibu Baby John | Minister for Labour and Employment | Chavara | Kollam | RSP |
| 8 | V. S. Sivakumar | Minister for Health & Devaswom | Thiruvananthapuram | Thiruvananthapuram | INC |
| 9 | V. K. Ebrahimkunju | Minister for Public works | Kalamassery | Ernakulam | IUML |
| 10 | K. P. Mohanan | Minister for Agriculture, Agriculture university and research, Warehousing and State Press and animal husbandry | Kuthuparamba | Kannur | SJD |
| 11 | P. J. Joseph | Minister for Water Resources, Irrigation and Inland Navigation | Thodupuzha | Idukki | KC |
| 12 | M. K. Muneer | Minister for Social Welfare & Grama Panchayath | Kozhikode South | Kozhikode | IUML |
| 13 | A.P. Anil Kumar | Minister for Tourism, Welfare of Scheduled Castes and Backward Classes | Vandur | Malappuram | INC |
| 14 | Adoor Prakash | Minister for Revenue and Coir | Konni | Pathanamthitta | INC |
| 15 | C. N. Balakrishnan | Minister for Co-operation, Khadi and Village Industries | Wadakkancherry | Thrissur | INC |
| 17 | P. K. Jayalakshmi | Minister for scheduled tribe, Youth welfare, State Archives & Museum-Zoo Departments | Mananthavady | Wayanad | INC |
| 18 | Anoop Jacob | Minister for Food, Civil supplies and Registration | Piravom | Ernakulam | KC |
| 19 | Manjalamkuzhi Ali | Minister for Urban Development Affairs, Minority welfare | Perintalmanna | Malappuram | IUML |
| 20 | P. K. Abdu Rabb | Minister for Education, Literacy and NCC | Tirurangadi | Malappuram | IUML |
Ex-Ministers
- T. M. Jacob - The Minister for Food, Civil supplies and Registration, died on 30 October 2011, and his son Anoop Jacob won from Piravom constituency in the by-election. He was given the same Ministry his father held and took office on 12 April 2012
- K. B. Ganesh Kumar, of Kerala Congress, a single-MLA constituent of the ruling UDF, resigned from the Council of Ministers on 1 April 2013 on personal issues. The Chief Minister then restructured the ministry by swapping different ministries between the existing ministers.
- K. M. Mani - Resigned from the post of Minister of Finance and Law on 10 November 2015 after the Kerala High Court's comments on his alleged involvement in Kerala BAR licence scam and bribery case.
- K. Babu - Resigned from the post of Minister of Excise, Fisheries and Ports on 23 January 2016 after the Kerala High Court's comments on his alleged involvement in Kerala Bar licence scam and bribery case.
Trivia
- Manjalamkuzhi Ali sworn in when UDF agreed Muslim League's claim for a fifth minister.
- Ramesh Chennithala of Indian National Congress, representing Haripad Constituency sworn in as the Home Minister on 1 January 2014 at Kerala Raj Bhavan.
- The first shuffling of portfolios occurred on 12 April 2012, with the inclusion of Manjalamkuzhi Ali and Anoop Jacob. The Chief Minister gave up the charge of Home Department. Thiruvanchoor Radhakrishnan, earlier in charge of Revenue Department was given the charge of Home Department, and Adoor Prakash, earlier in charge of Health Department, got Revenue Department. Health Department was handed over to V. S. Sivakumar, who was in charge of Transport Department, and Aryadan Muhammad was given the additional department of Transport. Some minor departments were also changed.