Seneca
- 2608 Seneca
- Cessna CH-1
- Edwin Drake
- LORAN-C transmitter Seneca
- Piper PA-34 Seneca
- Senakah
- Seneca (cigarette)
- Seneca (crater)
- Seneca (name)
- Seneca Army Depot
- Seneca Avenue (BMT Myrtle Avenue Line)
- Seneca Caverns (Ohio)
- Seneca Caverns (West Virginia)
- Seneca College
- Seneca County, New York
- Seneca County, Ohio
- Seneca Creek (North Fork South Branch Potomac River)
- Seneca Creek (Potomac River)
- Seneca Data
- Seneca Foods
- Seneca High School (disambiguation)
- Seneca Historic District (disambiguation)
- Seneca Institute – Seneca Junior College
- Seneca Lake (New York)
- Seneca Park
- Seneca Presbyterian Church
- Seneca River (New York)
- Seneca River (South Carolina)
- Seneca Rocks
- Seneca Station (Illinois)
- Seneca Township (disambiguation)
- Seneca Village
- Seneca language
- Seneca people
- Seneca station (Buffalo Metro Rail)
- Seneca the Elder
- Seneca the Younger
- Seneca, California
- Seneca, Illinois
- Seneca, Kansas
- Seneca, Maryland
- Seneca, Missouri
- Seneca, Nebraska
- Seneca, New Mexico
- Seneca, New York
- Seneca, Oregon
- Seneca, Pennsylvania
- Seneca, South Carolina
- Seneca, South Dakota
- Seneca, Wisconsin (disambiguation)
- Senecaville Lake
- Standards (Tortoise album)
- USCGC Seneca (1908)
- USCGC Seneca (WMEC-906)
- USS Seneca