Following his successful period at Faenza, he joined Genoa in 2002, but did not establish himself as a regular, playing just nine league games and scoring one goal in his first season of Serie B. Floccari took a step back into Serie C2, joining Rimini in co-ownership deal where he played and scored regularly. His goals contributed to successful promotions as Rimini went from playing in C2 to Serie B during his time there. The club also bought him outright in June 2003. In January 2006, Floccari's form was rewarded when Serie A strugglers Messina signed him as they looked to avoid relegation. Floccari scored three times as Messina survived thanks to the Calciopoli scandal. Two of those goals came in a 2–2 draw with Juventus. In June 2006, Messina bought the remain rights from Atalanta. In his first full season of Serie A in 2006–07, Floccari scored only twice as Messina finished last.
Atalanta
The Calabrese striker did not return to Serie B with his Messina teammates though. Atalanta re-signed him for a fee of €1.875 million. At Atalanta, Floccari battled for a starting place with the likes of Simone Inzaghi, Antonio Langella and Riccardo Zampagna. Floccari scored his first goal against league champions Inter and after Zampagna's bust-up with coach Luigi Delneri, Floccari's first-team opportunities increased, and he closed out the 2007–08 season with eight league goals. In 2008–09, Floccari improved yet again, scoring twelve league goals as Atalanta comfortably finished in mid table.
Return to Genoa
On 1 July 2009, Floccari returned to Genoa, the club he left in 2003, for €9.1 million. He scored on debut in a 4–1 win over Napoli and scored his first goal in the Europa League against Valencia. Having scored four league goals, Floccari was struggling to find space in the Genoa attack with coach Gian Piero Gasperini preferring the likes of Giuseppe Sculli and Raffaele Palladino. That transfer windows also saw a three-men three-way swap formed, which Floccari moved to Lazio to replace Goran Pandev who left for Inter on free transfer, and Genoa got David Suazo from Inter. The three strikers all had an unsuccessful days in the first half of the season.
Lazio
As a result, Floccari sealed a loan move to struggling Lazio, for €500,000. He made his debut after just one training session and scored twice in a 4–1 win over Livorno. Following that, Floccari made a surprising impact on the team, and was one of the key players in guiding the club to 12th in the league, well clear of the relegation zone. He missed a vital penalty in the defeat against Roma in the vital derby, but made up for it by scoring the winner against former club Genoa seven days later, a result that all but granted Lazio's Serie A status for 2010–11. At the end of season Lazio signed him permanently for a €8.5 million transfer fee having agreed a four-year contract.
On 11 January 2016, Floccari officially joined Serie A club Bologna for an undisclosed fee. He missed three weeks of the 2016–17 season through injury.
SPAL
On 19 January 2017, Floccari signed a one-year deal with Serie B side SPAL. Two days later, he made his debut for the club in a 2–0 league win over Benevento. Floccari's first goal in a SPAL shirt came in stoppage time to seal the victory for the home side, after defender Francesco Vicari gave them the lead just before the break. On 13 April 2019, he scored the winner in a shock 2–1 victory over reigning champions Juventus.
