In the primary held on October 4, 2003, Buffington, backed by the outgoing Senator Bean, led a four-candidate race with 10,458. In second place was the Democrat, Forrest Davis, who polled 9,403 votes. Two other Republicans finished behind, Doug Shurling, with 5,387 votes and Ted Roberts, 4,410. In that 68 percent of primary voters had chosen a Republican candidate, Davis withdrew from the November 15 general election, and Buffington won her seat by default. In 2007, Buffington won reelection by defeating the more conservative Republican attorney, and subsequent member of the Louisiana House of Representatives for District 5, Alan Seabaugh. She prevailed in the primary, 16,665 to Seabaugh's 14,725. De Soto Parish provided most of Buffington's margin of victory. Had the race been restricted to the majority of the precincts in Caddo Parish, Buffington would have won by only 277 votes. Seabaugh told The Shreveport Times that he had "met Sherri and she seems nice. But she just doesn't represent me. It begins and ends with her voting record. She runs as a Republican and votes like a Democrat." Buffington serves on these Senate committees: Environmental Quality, Finance, Health and Welfare, and Labor and Industrial Relations. She is also the vice chairman of the Select Women's and Children's Committee. In 2010, Buffington received a 61 percent rating from the Louisiana Association of Business and Industry, lower than most Republican legislators. In 2009, the Louisiana Federation of Independent Business rated her 70 percent. The Louisiana Family Forum rated her 13 percent in 2004, 33 percent in 2006, and 57 percent in 2007. After Buffington defeating Seabaugh, her Family Forum rating moved upward to 78 percent in 2008 and 90 percent in 2010. In 2009, she was ranked 100 percent by the Louisiana Right to Life Federation. In 2011, Buffington voted against legislation to amend the Smoke-free Air Act to bar smoking in bars and restaurants.
Reelection in 2011
Buffington won her third term in the primary election held on October 22, 2011, having defeated fellow Republican Troy Neal Terrell, 10,570 votes to 7,912, is the current mayor of Converse; a Republican, his term expires on December 31, 2020. Buffington is the second woman to hold the District 38 seat. The DemocratVirginia Shehee of Shreveport served in the slot from 1976 to 1980. Buffington is a daughter of Caddo Parish Commissioner Jim Smith, also of Keithville. Buffington is divorced from Jon Loyd Cheek of Shreveport. Her second husband, William Joseph "Joe" Buffington, is a Certified Public Accountant in Shreveport and the municipal finance director for Bossier City. The couple resides in Keithville. In 2016, as her Senate term ended, Buffington registered as a lobbyist for Willis-Knighton Health Systems, Prados and Associates, and the Louisiana Medicaid Physician IPA.