On 4 November 1844 Sir George Seymour, John Young Clarke, master, set sail from England, bound for Van Diemen's Land, Australia; she arrived at Hobart on 27 February 1845. She had embarked 345 male convicts and she landed 175 at Port Phillip and 169 at Hobart; one convict died on the voyage. She sailed for Calcutta on 27 June with 132 horses, and other cargo and passengers.
1849 emigrant voyage to Australia
Sir George Seymour sailed from Plymouth on 9 January 1849, bound for Geelong, Victoria. She was carrying 302 assisted immigrants and assorted cargo. She anchored off Port Henry on 14 May; she arrived at Melbourne 1 June. On 3 July she sailed from Sydney, bound for Singapore and Calcutta.
1850 emigrant voyage to New Zealand
In 1850 Sir George Seymour was one of the First Four Ships to carry emigrants from England to the new colony of Canterbury in New Zealand on behalf of the Canterbury Association. The other three ships were Cressy, Charlotte Jane, and Randolph. Sir George Seymour left Plymouth Sound, England around 11am on Sunday, 8 September 1850, with about 227 passengers. She arrived in Lyttelton at 10am on Tuesday, 17 December 1850. The passengers aboard the first four ships were referred to as "The Pilgrims". Their names are inscribed on marble plaques in Cathedral Square in the centre of Christchurch. The ship is remembered in the name of a road, George Seymour Quay, in the port town of Lyttelton.
John Charles Watts-Russell, politician and runholder
Later career and fate
In 1865 Sir George Seymour underwent repairs for damages. At the time her master was M'Ewen, her owner Higgins & Co., her homeport London, and her trade "Brs". A fire destroyed Sir George Seymour in 1867. She was carrying a cargo of coal from Liverpool to Bombay when the cargo suffered spontaneous combustion on 18 December 1867 at. Her crew abandoned her. Leda, which was on her way to Calcutta, rescued 15 crew members. Her entry in Lloyd's Register for 1867 carried the annotation "URNT". The listing gave her master as M'Ewen, but her homeport now was Glasgow, and her owner D. Law.