Sirohydrochlorin cobaltochelatase
In enzymology, a sirohydrochlorin cobaltochelatase is an enzyme that catalyzes the chemical reaction
In the forward direction of reactions towards cobalamin in anaerobic bacteria, the two substrates of this enzyme are sirohydrochlorin and Co2+; its two products are cobalt-sirohydrochlorin and H+.
This enzyme belongs to the family of lyases, specifically the "catch-all" class of lyases that do not fit into any other sub-class. The systematic name of this enzyme class is cobalt-sirohydrochlorin cobalt-lyase . Other names in common use include CbiK, CbiX, CbiXS, anaerobic cobalt chelatase, cobaltochelatase , and sirohydrochlorin cobalt-lyase . This enzyme is part of the biosynthetic pathway to cobalamin in bacteria such as Salmonella typhimurium and Bacillus megaterium. It has also been identified as the enzyme which inserts nickel into sirohydrochlorin in the biosynthesis of cofactor F430, reaction.As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and.
