Small nucleolar RNA SNORD64


SNORD64 is a non-coding RNA molecule which functions in the biogenesis of other small nuclear RNAs. This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA and also often referred to as a guide RNA.
SNORD64 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box and the D box. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.
snoRNA HBII-13 is expressed mainly in the tissues of brain, but is also in the lungs, the kidneys and muscle; however HBII-13 has no identified target RNA.
The HBII-13 gene is located in a 460 kb intron of the large paternally-expressed transcription unit along with several other snoRNAs HBII-436, HBII-437, HBII-438A/B and the clusters of HBII-85, HBII-52. This host gene is an antisense transcript to maternally expressed UBE3A gene.