Small nucleolar RNA SNORD66
SNORD66 is a non-coding RNA molecule which functions in the modification of other small nuclear RNAs. This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA and also often referred to as a guide RNA.
HBII-142 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box and the D box. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.
HBII-142 is the human orthologue of the mouse MBII-142 snoRNA and is predicted to guide 2'O-ribose methylation of 18S ribosomal RNA at residue C1272.
An experiment that looked at 22 different non-small-cell lung cancer tissues found that SNORD33, SNORD66 and SNORD76 were over-expressed relative to matched noncancerous lung tissues.
