Spillover infection, also known as pathogen spillover and spillover event, occurs when a reservoir population with a high pathogen prevalence comes into contact with a novel host population. The pathogen is transmitted from the reservoir population and may or may not be transmitted within the host population.
Spillover zoonoses
Spillover is a common event; in fact, more than two-thirds of human viruses are zoonotic. Most spillover events result in self-limited cases with no further human to human transmission, as occurs, for example, with rabies, anthrax, histoplasmosis or hidatidosis. Other zoonotic pathogens are able to be transmitted by humans to produce secondary cases and even to establish limited chains of transmission. Some examples are the Ebola and Marburg filoviruses, the MERS and SARS coronaviruses or some avian flu viruses. Finally, some few spillover events can result in the final adaptation of the microbe to the humans, who became a new stable reservoir, as occurred with the HIV virus resulting in the AIDS epidemic. In fact, most of the pathogens which are presently exclusive of humans were probably transmitted by other animals sometime in the past. If the history of mutual adaptation is long enough, permanent host-microbe associations can be established resulting in co-evolution, and even on permanent integration of the microbe genome in the human genome, as it is the case of endogenous viruses. The closer the two species are in phylogenetic terms, the easier it is for microbes to overcome the biological barrier to produce successful spillovers. For this reason, other mammals are the main source of zoonotic agents for humans. Zoonotic spillover has increased in the last 50 years, mainly due to the environmental impact of agriculture, that promotes deforestation, changing wildlife habitat, and the impacts of increased land use.
Intraspecies spillover
Commercially bred bumblebees used to pollinate greenhouses can be reservoirs for several pollinator parasites including the protozoans Crithidia bombi, and Apicystis bombi, the Microsporidians Nosema bombi and Nosema ceranae, plus viruses such as Deformed wing virus and the tracheal mites Locustacarus buchneri. Commercial bees that escape the glasshouse environment may then infect wild bee populations. Infection may be via direct interactions between managed and wild bees or via shared flower use and contamination. One study found that half of all wild bees found near greenhouses were infected with C. bombi. Rates and incidence of infection decline dramatically the further away from the greenhouses the wild bees are located. Instances of spillover between bumblebees are well documented across the world but particularly in Japan, North America and the United Kingdom.
