In 1861, Monsignor Steins, Vicar Apostolic of Bombay passing through Belgium, called Mother Marie Therese, Superior General and founder of the Daughters of the Cross, and asked for several of her sisters to work in the Indian mission field. Canon Habets, co-founder, advised the Sisters to offer themselves for the mission. The school was founded in 1862 by the planning of Monsignor Steins, Vicar Apostolic of Bombay of that time and five Sisters of the Cross. On 27 January 1862, the journey began. Five Sisters set off and arrived on 16 February in Bombay, where they received a hearty welcome from Bishop Steins. There the Sisters heard for the first time that they were to work in Karachi, and that he would travel along with them very shortly. Thus, on 13 March 1862, five Daughters of the Cross first set foot on the sandy soil of Sindh, and immediately began their apostolate to the people of Karachi. Five days later, on 18 March, school began with ten pupils; gradually the number of pupils increased. A new building was built, and inside the foundation stone was placed an elaborate inscription hoping that the building raised above it "might be the home whence good morals and sound learning may be diffused throughout this town and the Province of Sindh." In 1863 a new group of Sisters arrived. In 1869 an upper storey was added to the Convent, providing accommodation for the boarders and from January 1871 the institution was known as St Joseph's Covent. After many years in 1951 the college was built. After the new St Patrick's Church was built, the Convent acquired the use of the old Church, which was rebuilt into the present fine Hall, with a built-in stage. 1901 saw the building of the present Convent Chapel with the classrooms below. The roof of this was torn off six months later in a violent cyclone that swept over Karachi. In 1911, St Patrick's and St Joseph's held their golden jubilee with a combined P.T. display and the performance of a play, William Tell, in the G.P. Hall. That year five pupils, Ethel Raymond, Annie Rodrigues, Eugene Nunes, Mary Lastellino and Mary D'Souza, appeared for their Matriculation Examination, and all passed. Ethel Raymond passed 2nd in Sindh and won a scholarship. In 1958 the swimming pool was closed and transformed into the Lourdes House, and in 1965 a part of the garden saw the raising of the present Primary Block. With the creation of Pakistan a new challenge was thrown to the Sisters. The people who migrated to Pakistan were looking for schools for their children and the Sisters responded generously, stretching their capacity to the limit. Today the school has more than 2000 pupils on its rolls. On 18 July 1989, the mayor of Faisalabad and Belgian ambassador to Pakistan renamed a public square "Belgium Square" to honor Belgian nuns who founded St. Joseph’s in Karachi 125 years ago.
Principals
Extracurricular activities
Clubs. The Annual Sports Day is an event organized by much enthusiasm and hard-work. The activities include march past, races, disc and javelin throw, and P.T displays. The field trips too are a norm and feature educational trips to various museums, a recent trip to Lahore, and even fun visits to melas and cinemas. The school is proud of its Annual Computer, Art, and Science Exhibition which is visited by students belonging to various prestigious schools in Karachi. Other SJC Events include the Milaad, Naat Competitions, Feast Day Celebration, Independence Day Celebrations, and the Christmas Concert among many others.
Clubs
Clubs at the school include Scrabble Club, Art Club, Debating Society, Dramatics Society, Book Club, Sewing Club, and Chess Club.