Born in Pontiac, Michigan, Howe was a two-time All-Big Ten selection at the University of Michigan. He made his Major League debut at the age of 22 in and would eventually become the National League Rookie of the Year that year, the second in a string of four Dodger rookies of the year. He saved 17 games during his ROY season, establishing a new rookie record. The following year, Howe helped the Dodgers win the World Series against the New York Yankees. Howe's career was plagued by alcohol and cocaine abuse; he first checked himself into a substance abuse clinic in, but a relapse resulted in him being suspended for the entire season. Over the course of his 17-year career, Howe would be suspended seven times. After briefly pitching for the Minnesota Twins and Texas Rangers and being out of the major leagues for four years, Howe signed with the Yankees, where he once again pitched effectively. However, in, Howe became the second player to be banned from baseballfor life because of substance abuse. He successfully appealed the ban and re-signed with the Yankees, where he had one final great season in, recording 15 saves and a 1.80 earned run average as the Yankees' closer. He failed to repeat the performance the following year and was relegated to a setup role, and was released in June after posting an 0–1 record with a 6.35 ERA. Howe finished his career in 1997 playing with the Sioux Falls Canaries of the independent Northern League. For his career, Howe posted a record of 47 wins, 41 losses, 91 saves, and a 3.03 ERA in 497 games.
Autobiography
Howe published an autobiography in 1989, the middle of his baseball career. The book, Between the Lines: One Athlete's Struggle to Escape the Nightmare of Addiction, described his chemical dependency and hope for recovery based upon his newfound commitment to evangelical Christianity. The book was co-written with Jim Greenfield, who later became a talk radio host on several stations in the Portland, OR, area.
After baseball
Following his retirement from baseball, Howe worked in Lake Havasu City, Arizona, as a self-employed framing contractor. His company's name was All Star Framing. On April 28, 2006, Howe's pickup truck rolled over in Coachella, California, and he was killed. He was not wearing a seat belt at the time of the crash. The toxicology reports following his autopsy indicated he had methamphetamine in his system.