The Minnesota Twins selected Lombardozzi in the ninth round of the 1981 MLB Draft after which he was assigned to the Elizabethton Twins in the rookie-level Appalachian League where he hit.321 with 6 home runs and 38 RBI in 65 games. The following years, he made steady progress through the Twins' organization spending 1982 at class-A Visalia, 1983 at AA Orlando, and 1984 at AAA Toledo. After returning to Toledo in 1985, he made his major league debut with the Twins on July 12 and split the rest of the season between the majors and AAA. , Ronald Reagan and Lombardozzi at the White House in 1987 Lombardozzi went north with the Twins following spring training in 1986 and became the starting second baseman for the team for the next three seasons. In 1987, Lombardozzi was on the team when they won the World Series against the St. Louis Cardinals. He led all hitters in that World Series with a.412 batting average. He also held the record for the longest last name of any player to hit a postseason home run, hitting a Game 1, two-run home run off Cardinal Bob Forsch, until it was broken by Doug Mientkiewicz of the Minnesota Twins in 2002. Lombardozzi also knocked in the winning run in Game 6 as his RBI single broke up a 5th Inning 5-5 tie that eventually lead to an 11-6 Twins' victory. Despite his World Series heroics and gold glove-caliber fielding, Lombardozzi was never able to hit above.238 for the Twins and hit only.209 with 3 home runs and 27 RBI in 1989. Following both the 1987 and 1988 seasons, the Twins, looking to add some more offense at the position, traded first for Cardinal Tommy Herr and then New York Mets second baseman Wally Backman. Being the odd man out, Lombardozzi split time at second in 1988 and finally was traded to the Houston Astros at the end of spring training in 1989. However, Lombardozzi was never able to either supplant Bill Doran at second or stay with the big club and spent 1989 and 1990 shuttling between Houston and the minors. After playing his last game in Houston on 11 April 1990 he was released by the Astros on May 28. After being signed by the Detroit Tigers on June 9, Lombardozzi was designated to AAA Toledo where he spent the rest of the season. Lobardozzi was then released and he decided to retire at age 30.
Retirement
After his playing days ended, Lombardozzi moved to his home in Columbia, Maryland and focused on his family. He ran a small business, coached youth baseball, and spent time with his two children. After being away from the game for 18 years, Lombardozzi was hired by the Pittsburgh Pirates in December 2009 to be their minor league fielding coordinator, taking the place of Carlos García, who was hired as the Pirates' first base/infield coach. His son, Steve Lombardozzi Jr., formerly played professionally for the Washington Nationals organization.
